South African Malaria Initiative

Working together to combat malaria.

"...information at the molecular level is vital to gain insights
into the pathogenesis of malaria, and potentially offers
the opportunity to develop better drugs."

~ Subra Suresh

SAMI Documents

 

SAMI research projects

Drug discovery:

- Exploiting the utilisation of coenzyme A and pantothenate by the malaria parasite P. falciparum as an antimalarial drug target

- Novel antimalarial agents targeting Plasmodium falciparum spermidine synthase by way of rational-based drug design

- Plasmodium falciparum GTP cyclohydrolase I (PfGCHI): Optimisation of purification and activity, structure determination and inhibition studies

- Quinoline and non-quinoline haemozoin inhibitors that circumvent chloroquine resistance

- Signalling pathways controlling the cell cycle of Plasmodium falciparum as antimalarial drug target

- Structure-based drug discovery against a novel antimalarial drug target, AdoMetDC/ODC

 

Diagnostics:

- Diagnostic development

- SNP Biomarkers

 

 

Call for research proposals

 

 

Founding workshop presentations

 

SAMI launch presentations